Helicobacter pylori positivity is usually eradicated by quadruple therapy, including 2 antibiotics (e.g., amoxicillin, clarithromycin), 1 proton pump inhibitor (e.g., omeprazole), and 1 bismuth (e.g., bismuth potassium citrate), with dietary modifications. 1. Quadruple therapy (1) Antibiotics: Helicobacter pylori positive need to be eradicated treatment, generally need 2 kinds of antibiotics combined anti-infection, at present, the commonly used clinical drugs are amoxicillin and clarithromycin, in addition to furazolidone, metronidazole, etc., according to the patient with or without allergies and other specific circumstances to choose the drug. (2) Proton pump inhibitors: commonly used are omeprazole, esomeprazole, etc., which can play the role of acid suppression. (3) Bismuth: commonly used drugs are bismuth potassium citrate, colloidal bismuth pectin, etc., which can play the role of protecting gastric mucosa. 2. Diet regulation In addition to oral medication, we should pay attention to dietary hygiene, meal portioning to avoid cross-infection. Because Helicobacter pylori is prone to recurrence, it should be applied according to the course of treatment, and the drugs should be used under the guidance of a doctor, and it is recommended to seek medical treatment in time.