Urine microalbumin 450mg / L is generally not serious, but whether it is serious should be based on the causes of its elevation to determine the causes of elevated proteinuria, including physiological and pathological. Physiologic proteinuria is usually not serious, while pathologic proteinuria is relatively serious.
Albumin is one of the important plasma proteins, under normal circumstances, the molecular weight of albumin is large, can not cross the glomerular basement membrane, so the normal value of urinary microalbumin <30mg / L. The urine microalbumin is not important in the plasma protein.
Physiological conditions, such as chills, high fever, strenuous exercise, etc. will appear its transient elevation, after the elimination of the causative factors, usually can gradually return to normal, usually not serious.
Pathological conditions, such as acute and chronic nephritis, the glomerular basement membrane is damaged, resulting in changes in permeability, albumin can be filtered out of the glomerulus and appear in the urine. When urinary microalbumin reaches 450mg/L, it may be caused by glomerular inflammation or other diseases resulting in altered renal permeability, which is relatively serious.
It is recommended that patients with abnormal urinary microalbumin go to the hospital in time to improve the relevant examinations, and further diagnosis and treatment under the guidance of physicians.