The first step is to actively identify the cause of the toe ulcer. Diabetic foot requires glucose-lowering drugs such as metformin and insulin preparations to control blood sugar; peripheral vascular disease usually requires anti-platelet aggregation drugs such as aspirin and lipid-lowering drugs such as simvastatin; tinea pedis requires topical anti-fungal drugs such as ketoconazole and terbinafine cream. In addition, it is important to keep the ulcerated area clean and topical medication to promote wound healing, such as recombinant bovine alkaline growth factor, can also be effective.