Prolactinoma is usually due to pituitary lesions or hyperpituitary gland, which causes excessive secretion of prolactin and causes tumors. Surgery is usually used to remove the tumor, and medication and radiation therapy are also available. For hypothalamic and pituitary lesions, the specific cause should be identified and the corresponding treatment should be carried out. Prolactinoma seriously affects health and can cause instability of cranial pressure, producing vomiting, nausea, fainting, and even pituitary stroke, producing severe headache, nausea, and shock. In the early stages of the disease, the tumor is often not very large and there is no hematologic disease, and medication can be administered using dopamine agonists. Allergy testing is required during the administration of the medication. If one has already undergone pterygoid sinus surgery, the medication period will not be very long and it will be easier to see results. Pterygoid sinus surgery is often performed through the nasal cavity and will remove the tumor around the pituitary gland appropriately. This is for larger tumors, which will face postoperative complications after surgery, and attention should be paid to the examination of the nasal area for stages and the cranial cavity for infectivity. For advanced stages of the disease, where the tumor is relatively large and has metastasized and is not easy to do surgery, radiotherapy can be chosen to alleviate the further increase of the tumor and prolong the survival of the patient. During the treatment of prolactinoma, it is important to strictly follow the doctor’s instructions and the process of examination to determine the stage of the disease and then choose the appropriate method of treatment. This disease is prone to recurrence, so it is important to pay attention to regular checkups and take medication on time after treatment.