It is not clear how many generations ankylosing spondylitis will be inherited. Ankylosing spondylitis may be genetically related, but not all patients will pass it on to their offspring. There is no clear clinical data on how many generations ankylosing spondylitis can be inherited. The cause of ankylosing spondylitis is unclear and may be related to genetic predisposition, but it does not mean that people with a history of ankylosing spondylitis in their family will definitely develop the disease. In addition, ankylosing spondylitis is associated with infectious, environmental, and immunologic factors, which should be recognized. Ankylosing spondylitis is a chronic autoinflammatory disease, which is characterized by lower back pain with morning stiffness and swelling in the bones and joints, causing serious impact on quality of life and health. Since the disease is incurable and will progressively worsen, it is necessary to actively cooperate with the doctor in order to control the disease and improve the discomfort. People with a family history of AS are advised to seek regular medical checkups to monitor their health. Patients who are diagnosed with ankylosing spondylitis should go to the hospital in time to avoid delays.