Bone metastasis in advanced stage of lung cancer leads to general pain, and effective analgesic treatment is needed to relieve the pain. Analgesic drugs include aspirin, celecoxib, ibuprofen, etc. These drugs are non-steroidal drugs, which can improve mild pain. If the pain is moderate, moderate pain medications such as oxycodone, tramadol and aminoglutethimide need to be given, which can effectively improve the pain and can be stabilized for about 1 day. If the cancer pain is severe and the pain is frequent, strong morphine as well as fentanyl analgesics need to be given. Morphine can be given orally or by subcutaneous injection to relieve cancer pain quickly. If the effect of morphine is still not obvious, fentanyl can be used as a skin patch, which is 10 times more effective than morphine in relieving pain and can be administered once for 72 hours, which is convenient for patients and can also effectively relieve pain. In addition, radiotherapy and bisphosphonates can be given to the site of severe pain.