The four stages of diabetes development mainly refer to the four stages of type 2 diabetes development, because the pathogenesis of type 2 diabetes is mainly based on insulin resistance, and late insulin deficiency, rather than an absolute lack of insulin like type 1 diabetes. type 2 diabetes development: the first stage, with genetic susceptibility, because type 2 diabetes is not a single gene disease, but a polygenic disease, the onset of In addition to genetic susceptibility, there are also environmental factors and other related factors. In the second stage, the disease is mainly characterized by hyperinsulinemia and insulin resistance, and insulin resistance and insulin secretion disorder are the two basic links and main features in the pathogenesis of type 2 diabetes. The third stage is mainly hypoglycemic tolerance. Patients with type 2 diabetes go through hypoglycemic tolerance, which is pre-diabetes, and may be dominated by impaired fasting glucose regulation or abnormal postprandial glucose regulation, but have not yet reached the diagnostic criteria for diabetes. The fourth stage is the emergence of clinical diabetes, where the patient’s monitored blood glucose values have reached the diagnostic criteria for diabetes.