Anal fissures may lead to local infection of the fissure if they are prolonged. In case of fissure local infection, antibiotics are mainly used. Since most of the fissure infections are caused by E. coli or anaerobic bacteria, antibiotics can be chosen from broad-spectrum antibiotics and anti-anaerobic antibiotics, or both. In addition, patients with anal fissures should also pay attention to their diet, because most of the fissures are caused by constipation and dry stools. Therefore, patients should usually take a light diet, eat more vegetables, fruits and other coarse fiber food, avoid spicy and stimulating food, keep the stool soft and fluent, develop good bowel habits, and develop the habit of taking a warm water bath after each bowel movement.