Mental illness is a type of chronic and intractable disease, currently commonly used mainly medication, psychotherapy, physical therapy, but still a kind of treatment for intractable mental illness may be the last trick, that is, psychosurgery, also called neuromodulation technology, or minimally invasive radiofrequency ablation. Modern scientific research has found that mental disorders are caused by abnormalities in brain regions and neural circuits, neurotransmitter function, etc., and that medication mainly works by regulating neurotransmitters. However, since mental disorders have become chronic and intractable diseases, they are resistant to drugs and cannot respond to drugs, which makes drug treatment ineffective. The key to surgical treatment is to use brain stereotactic 3D positioning technology in order to precisely locate in order to target deep brain nuclei or even to target nuclei subregions, which are more than a few millimeters in size. If you cannot precisely locate the nucleus, or if you miss the nucleus, the effect is not good, and serious complications may arise. In addition, it is impossible to keep the head absolutely still during the treatment, especially when a little cerebrospinal fluid will flow out during the operation, which will cause the brain volume to change, which will make the position of the brain structure to move, and the position of the brain will also move when the person is breathing, which requires the operation to make the RF needle also move with the subtle movement of the brain structure, and always make the RF needle accurately align with the operation target. Therefore, in order to ensure the accuracy of the surgery, precise positioning technology is necessary to ensure the accuracy of the surgery. Only the nerve navigation positioning technology, which is developed using the principle of satellite navigation positioning technology and is more accurate than satellite navigation positioning with a positioning error of less than ±0.3mm, can achieve precise positioning and guarantee the efficacy. It is not enough to have such positioning technology, but also to have neuroimaging technology, such as CT and MRI and DTI technology to fully display the microstructure of the brain, and then satellite navigation positioning to align the brain structure, i.e., to the surgical target, for ablation to ensure the efficacy of the surgery. The surgical treatment of psychiatric disorders has a history of 130 years, and the surgical targets used have been clinically proven to be safe and effective for 60 to 80 years. Our team has treated more than 2,800 cases of various refractory mental illnesses, drug dependence, and epilepsy-induced mental disorders in the past 10 years, and the safety and efficacy are satisfactory. We have followed up 400 cases from 1 to 4 years after surgery, with an average of 2.7 years, and the efficiency rate is 88%, of which 48% have reached clinical recovery, and two-thirds of the patients can go out to work after surgery. This technology has saved many patients and families and enabled them to lead a harmonious and dignified life. It is understood that many psychiatric hospitals are now preparing to introduce this technology, and we are optimistic that a new treatment situation for mental illness will emerge, so let us look forward to it.