A child’s cough, to determine whether it is caused by mycoplasma infection, can be clarified from the characteristics of the child’s cough as well as laboratory tests. If the child is mycoplasma infection caused by coughing, coughing is often violent, irritating dry cough, some children will be accompanied by fever, wheezing, coughing symptoms are usually at night, cough duration is longer, lung auscultation of wet rales is relatively rare. In mycoplasma infection, routine blood tests usually show a normal white blood cell count, an increased proportion of neutrophils, positive mycoplasma antibodies, and mycoplasma DNA or RNA can be positive. When a child’s cough is considered to be caused by mycoplasma infection, it is necessary to take the child to the hospital pediatrics, after a clear diagnosis can be given under the guidance of the doctor macrolide antibiotic anti-infective treatment.