Condyloma acuminatum is a benign superfluous organism of the skin and mucous membranes caused by the human papilloma virus, with a recurrence rate of 65%. Reducing recurrence is a major problem in the treatment of condyloma acuminatum. Human papillomavirus can infect and replicate in keratin-forming cells within the epidermis, or lurk in that cell. Studies have shown that HPV infection can be present in the skin within approximately 1.0 cm of the wart around the condyloma acuminatum. The recurrence of warts is partly due to the presence of subclinical or latent infection with HPV. Traditional treatments such as CO2 laser and liquid nitrogen freezing have difficulty in solving this problem, while ALA photodynamic therapy has significant advantages in this regard. Studies have shown that fluorescence of protoporphyrin IX can be seen in areas of HPV subclinical and latent infections after topical application of 5-aminoketovaleric acid (ALA), implying that photodynamic therapy has a therapeutic effect on HPV subclinical and latent infections as well, which in turn significantly reduces the recurrence rate. For acromegaly in the male urethra, many hospitals currently tend to use destructive therapies such as laser, freezing and electrocautery. Due to the anatomical characteristics of the male urethra, traditional treatments tend to leave atrophic scars and produce urethral strictures after surgery. ALA-PDT is a safe and effective treatment method as it has few and mild local adverse effects, no trauma, no infection and no scar formation.