The main features of nephropathy are pallor and puffiness of the eyelids and face, as well as a pale tongue with teeth marks on the edges, mostly due to chronic kidney disease. Pallor is mainly due to renal anemia, which is caused by the decrease of erythropoietin due to renal failure after chronic kidney disease. The puffiness of eyelids and face is mainly caused by the decrease of glomerular filtration rate and the disorder of water metabolism in kidney. In the early stage, Chinese medicine can be used to regulate the disease, which can strengthen the spleen, benefit the kidneys, release turbidity and detoxify the kidneys, which can improve the increase of toxins in chronic kidney disease and slow down the failure of kidney function. If the kidney disease is more serious, especially to the uremic stage, it needs to be improved by kidney replacement therapy.