Side effects of Angong Niuhuang Pills include hypothermia due to improper use, allergic reactions, contraindication for patients with coldness and dizziness, and caution for pregnant women and athletes. Angong Niuhuang Pills is a proprietary Chinese medicine with the effects of clearing away heat and detoxification (removing heat and toxicity from the body), suppressing fright and opening up the mind, and the ingredients of the medicine include ox horn, concentrated powder of buffalo horn, musk, pearl, yellow rhubarb, scutellaria, gardenia, vermilion, andrographis, tulip, and ice chips. Contraindications for the use of the drug include cold closure and dizziness, caution in pregnant women, liver and kidney insufficiency, athletes, allergy. Indications for the use of the drug include fever, evil into the pericardium, febrile convulsions (convulsions and seizures due to high fever), delirium tremens (delirium, nonsense); as well as stroke coma and cerebral hemorrhage, meningitis, encephalitis, septicemia, and toxic encephalopathy accompanied by the above symptoms. Improper use of the drug may cause hypothermia, and there have also been side effects of allergic reactions in users of the drug. The diet during the medication should be light, and spicy and greasy food should not be consumed. Specific drug use should be under the guidance of a specialist, not self-medication.