Creatinine 160umol/L is more likely to come down if it is acute kidney injury; if it is chronic kidney failure, it is less likely to come down. Creatinine 160umol/L, higher than the upper limit of 110umol/L normal value, suggests renal failure, but renal failure is divided into acute and chronic. Acute renal failure, also called acute kidney injury, is mostly caused by certain nephrotoxic drugs. After avoiding exposure to these drugs and maintaining water-electrolyte balance, nutritional support and other treatments, renal function will gradually recover and creatinine will naturally come down. If it is chronic renal failure, mostly caused by diabetic nephropathy, chronic glomerulonephritis and other chronic diseases, then the creatinine will be reduced very little. However, you can also apply the detoxification medicines such as urethane granules and Haikun Kidney Xie capsule to take care of your kidneys, which can prevent the creatinine from growing too fast and enter the uremia stage as late as possible.