Improper use of Orlistat may cause liver damage, i.e. drug-related liver injury, so it should be used under the guidance of a doctor. When the dose is too high and the duration of administration is too long, the drug may lead to liver cell damage after absorption by the liver, which will not only cause liver damage, but also kidney damage and even multi-organ failure. Therefore, when taking orlistat, the dose and dosing cycle should not be adjusted privately. If abdominal pain, jaundice, dark urine and pain in the right upper abdomen occur during the medication period, liver damage may be considered and it is recommended to stop the medication immediately and seek medical examination and treatment in a timely manner. Generally, the drugs are taken by oral administration such as Tian Qing Gan Ping, glutathione, compound glycyrrhizin tablets for anti-inflammation and liver protection, and potassium magnesium menthylate and ursodeoxycholic acid to promote liver cell repair. In addition, it is recommended to drink more water during medication administration, which can promote drug metabolism to avoid aggravating liver damage. In general, the prognosis of acute drug-related liver damage is mostly good through timely diagnosis and timely discontinuation of drugs, while a few acute severe hepatitis require artificial liver support or liver transplantation treatment.