Hepatitis B minor triple-positive refers to positive results for hepatitis B surface antigen (HBsAg), hepatitis B e antibody (HBeAb) and hepatitis B core antibody (HBcAb) in the five hepatitis B tests. These patients are infectious, but relatively less so. Minor triplets include inactive HBsAg carriers and HBeAg-negative chronic hepatitis B. Inactive HBsAg carriers are patients with positive hepatitis B surface antigen (HBSAg), negative hepatitis B e antigen (HBeAg) and positive or negative hepatitis B e antibody (HBeAb), undetectable or below the minimum detectable level of hepatitis B virus DNA, with more than three consecutive follow-up visits within one year, and transaminases within the normal range. Hepatitis B surface antigen (HBsAg) and hepatitis B virus DNA positive, hepatitis B e antibody (HBeAb) positive or negative, serum aminotransferase persistently or repeatedly abnormal, or liver histological examination suggesting hepatitis lesions. Simply put, the former are hepatitis B virus carriers without hepatitis manifestations, and the latter have chronic liver damage manifestations. In terms of treatment, patients with small triplets should improve hepatitis B virus DNA testing, liver ultrasound if necessary to complete liver biopsy and other related laboratory tests to assess the patient’s condition, and then develop standardized liver protection, antiviral, immunomodulatory and other treatment measures. To sum up, patients with hepatitis B minor triplet have a certain degree of contagiousness, patients should promptly consult a doctor to develop a suitable treatment plan and adhere to regular review and adjustment of treatment.