Cranial defect is a relatively common craniocerebral disorder, many reasons can cause cranial defect, such as traffic accidents, production safety accidents, falling objects, fighting, cranio-cerebral surgery and so on, can cause cranial defect. Cranial defects may cause a series of uncomfortable symptoms, and very unsafe, external impact bump may directly hurt the brain, and cranial defects after the skull is very unattractive, resulting in psychological discomfort and even psychological disorders. Therefore, after the occurrence of cranial defects, it is necessary to carry out cranial repair in a timely manner. However, many patients may realize that there is a risk of infection after cranial repair, and are deterred from doing so. In fact, there is no need to worry too much about this, not only cranial bone repair, but also many surgical procedures have the risk of infection, but you should not choke on it. What everyone needs to do is minimize the risk of infection, and this is something that doctors and patients need to work together to do. How do you avoid infection in cranial bone repair? The first is the surgical technique and perioperative care, and the second is the choice of cranial repair materials. Titanium mesh, which is widely used in clinical practice, may have a relatively high risk of postoperative infection, while a more advanced polyether ether ketone (PEEK) material has a much better performance and is less likely to cause postoperative infection. The rate of surgical infection is also closely related to the skill of the surgeon and the overall perioperative management of the team. Strict implementation of aseptic operation and perfect perioperative management are required before, during and after surgery to ensure the treatment effect and prevent patients from developing skull repair infection. Mr. Li, who was discharged from the hospital some time ago, suffered from severe craniocerebral trauma due to a fall from a height, and was left with a cranial defect after local emergency treatment. Recently, he was treated in our clinic, and the team carried out PEEK cranioplasty, after which the shape of the skull was restored to its original form, which was aesthetically pleasing and symmetrical, and his spirit and mood were better than before the surgery, and the symptoms of dizziness that had been present before had disappeared after the restoration surgery, with no infection at all. The whole process was completely free of infection. The patient has been discharged from the hospital. Our team has widely used the excellent polyetheretherketone PEEK material to carry out PEEK cranioplasty, which has achieved good results in clinical practice and obtained good feedback from patients. With the excellent performance of the materials we use, advanced technology, and perfect team management, we are not only able to achieve good cranial bone repair results, but also well avoid cranial bone repair infection, so that the majority of patients with cranial bone defects recover smoothly, find self-confidence, and start a new life.