Cystic solid nodules after resection of the left lobe of the liver may be caused by hepatic cysts, hepatic hemangioma, hepatocellular carcinoma, etc., which can be followed up for observation, surgical resection or liver transplantation. 1. Liver cysts: after resection of the left lobe of the liver, liver cysts may occur in the remaining liver tissue due to bile duct blockage, stones, etc. Small liver cysts usually do not need special treatment and only need observation and follow-up; larger liver cysts may be treated with cystectomy or liver transplantation. 2. Hepatic hemangioma: Hepatic hemangioma can occur in the remaining liver tissue after resection of the left lobe of the liver, manifesting as cystic solid nodules. Small asymptomatic hepatic hemangioma only needs observation and follow-up, while large hepatic hemangioma can be treated with hepatic artery ligation or liver transplantation. 3. Hepatocellular carcinoma: Hepatocellular carcinoma can occur in liver tissues after left lobectomy due to hepatitis B virus infection and tumor recurrence, etc. It can be treated by radiofrequency ablation, percutaneous intratumoral injection of anhydrous ethanol, liver transplantation, etc. It can also be treated by targeted drugs such as oral sorafenib. Cystic solid nodules after resection of the left lobe of the liver should go to the hospital in time to improve the examination and give targeted treatment after clarifying the cause of the disease.