The corners of the mouth on fire can take heat-clearing and detoxifying (clearing heat and toxicity from the body) medicines such as Ox-Huang Detoxifying Tablets. Niu Huang Detoxifying Tablets are mainly composed of xiong huang, rhubarb, artificial oxalis, platycodon, gypsum, licorice, icicle, scutellaria and other traditional Chinese medicines, which have the effect of clearing heat and detoxification, and can be clinically used to treat diseases with symptoms such as internal heat, sores on the mouth and tongue, sore throat, swollen eyes, swollen gums and so on. Adverse reactions such as dry mouth, nausea, abdominal pain, diarrhea, skin rash may occur when taking Niu Huang Detoxification Tablet, which is prohibited for lactating women and pregnant women, infants and young children, and for those who are allergic to the ingredients contained in it. In addition, patients should eat more fresh vegetables and fruits, keep bowel movement, keep the skin around the mouth dry and hygienic, moderate exercise to enhance physical fitness. Niu Huang detoxification tablets need to be taken under the guidance of traditional Chinese medicine, to avoid self-medication to affect the health of the body.