Symptoms are indeterminate in patients with respiratory failure 10 days before death, but advanced respiratory failure may present with extreme dyspnea, neuropsychiatric symptoms, and corresponding symptoms in the peripheral circulation. 1. Dyspnea: patients with respiratory failure may have different degrees of dyspnea before death, which is characterized by respiratory effort, prolonged expiration, etc. In severe cases, changes in respiratory rhythm may also occur, such as shallow-fast respiration, shallow-slow respiration, tidal respiration and so on. 2. Neuropsychiatric symptoms: long-term hypoxia and carbon dioxide retention will seriously affect the brain function and cause a series of neuropsychiatric symptoms, such as irritability, insomnia, delirium, day and night, etc. In severe cases, pulmonary encephalopathy symptoms will occur, which manifests as indifference, convulsions, muscle tremor, coma until death. 3. Corresponding symptoms of peripheral circulation: prolonged hypoxia and carbon dioxide retention will cause cardiac and peripheral vascular function abnormality, and there will be superficial venous congestion, skin and mucous membrane congestion, excessive sweating, and increased heart rate. Once diagnosed with respiratory failure, you should go to a regular hospital in time, cooperate with the doctor to improve the relevant examination and standardized treatment.