There are many causes of joint pain, but systemic infection caused by a novel coronavirus can also cause joint pain. Infection with a novel coronavirus can cause a systemic inflammatory response, which can lead to synovial fluid accumulation in the joints and generally cause pain in multiple joints throughout the body, usually without organic lesions in the joints and usually with acute onset. Other causes of joint pain include osteoporosis and osteoarthritis, which can also lead to joint pain, usually in large joints, such as rheumatoid arthritis of the knee joint can also lead to joint pain, usually in small joints, such as the joints of the hand, generally symmetrical attacks, blood tests can find elevated rheumatoid factor.