The main difference between nosebleeds of liver cancer patients and those of usual patients is that the usual nosebleeds are caused by specific blood diseases or by dry weather or by external forces, the main difference between nosebleeds of liver cancer and the above-mentioned nosebleeds is that the pathogenesis is different, which is its main characteristic. Therefore, for this relevant feature of nosebleeding in liver cancer, symptomatic treatment with drugs to improve coagulation mechanism and hemostasis function can be used. Patients with hepatocellular carcinoma must protect the nasal cavity, oral mucosa, and related parts of skin mucosa to prevent inducing rebleeding.