Damage to the skin barrier may be caused by environmental factors, chemical stimulation, inflammatory reactions, etc. 1. Environmental factors: wind, sand and dust, frequent friction and pulling, hot and cold stimulation, and lack of attention to sun protection can cause thinning of the stratum corneum, which reduces the water content of the skin and leads to impaired skin barrier function. 2. Chemical stimulation: the frequent use of irritating skin care products, drugs, or contact with other chemicals containing strong acid, alkali ingredients, as well as long-term use of glucocorticosteroids and other stimulation of the skin, making the skin peeling and flaking, resulting in impaired skin barrier function. 3. Inflammatory response: Suffering from certain skin diseases, such as acne, seborrheic dermatitis, rosacea, etc. can damage the skin stratum corneum, resulting in impaired skin barrier function. There are many causes of impaired skin barrier, so it is recommended that patients go to the hospital, consult a professional doctor for detailed advice, and follow the doctor’s instructions for treatment.