Pulsed dye laser (SPTL) wavelength 585nm, pulse width 50ms, pulse energy density 3~10J/cm2; Nd: YAG laser, wavelength 10645nm, output power 0~100W, continuously adjustable, the fiber core diameter of 0.5mm, spot diameter of 2mm; pulsed CO2 laser, wavelength 10.6um, output power 0~20W, the following five methods of treatment: 1, SPTL laser + prednisone (treatment group 1) eye, face, ear, vulva, labia rapid growth of capillary hemangiomas and strawberry hemangiomas. The following five methods of treatment: 1, SPTL laser + prednisone (treatment of 1 group) eyes, face, ears, perineum, labia fast-growing capillary hemangiomas and strawberry hemangiomas 580 cases, of which 300 cases in the treatment group, given to the prednisone 2mg (kg?d) orally, the decreasing method and the observation of the side effects of hormones, to prevent the dye. During the medication period, SPTL laser irradiation was given to the lesions once a month, and the irradiation energy density and spot size were determined according to the size of the lesion, the location, and the height of the lesion, and the lesion turned from bright red to brownish-gray color immediately after the treatment was considered to be effective. After the operation, antibiotic ointment was applied to keep the local area dry and remove the scabs by themselves. In the control group, 280 cases were treated with SPTL laser only, and the method was the same as above. The shrinkage of hemangioma in the 2 groups was <30%, which was considered invalid and the treatment was stopped. 2.Pingyangmycin+YAG laser group (2 groups) Oral hemangioma 102 cases, including 50 cases in the treatment group, 8mg of pingyangmycin+4m1 of physiological saline+1% of lidocaine lml appropriate amount of mixing, routine disinfection will be uniformly injected into the tumor to cause whitening of foci, every l~2 weeks for the first time. The total amount of the drug was <40mg, and the thickness of the tumor was about 1cm. 1 week after the drug injection, the tumor was irradiated with Nd:YAG laser, with a power of 10-20 W, at a distance of 0.2-0.4m, and a time of 1-2s, so that the tumor was whitened and contracted. If the tumor was >5 m2, the laser was used to irradiate the tumor in “scattered” or “fence-like” stages. After the operation, apply povidone iodine on the surface to keep it clean and sterile. 3.SPTL laser + tretinoin group (treatment of 3 groups) 238 cases of cavernous hemangioma in palm, finger joints, perineum, labia hair face and neck, using SPI’L laser irradiation of the lesion for 1-2 times, to be thinned out on the surface of the lesion, the color becomes lighter, tretinoin 10mg + 1% light lidocaine 1ml mixing injection of cavernous hemangioma protruding parts of the whiteness. 2 methods alternately once a month, and the surface of the planing surface coated with polyvidone iodine to keep clean and aseptic. methods were alternated once a month, resulting in the disappearance of the red color of the skin surface and the disappearance of the subcutaneous cavernous body or a hard nodule. The control group was treated with SPTL laser only. 4, SPTL laser + CO: laser group (treatment of 4 groups), hypertrophic nodular nevus erythematosus. SPTI laser irradiation of lesions, the use of overlapping light spots, no 2 ~ 3 months of treatment once, the skin surface red subsides 30 ~ 40%, lesions thinning nodules relatively more prominent (generally after 2 treatments), the use of power of 3, 0 ~ 3, 5W pulsed CO2 laser vaporization, carbonization of the tumor until the lesion is all flat, with wound healing. All flatten, with half a month after wound healing, and then use SPTL laser irradiation. 5.Surgery comprehensive group. The aneurysm ligation is carried out first to remove the tumor in the blood sinus cavity, and SPTL laser irradiation of the surface of the lesion is carried out after 2 weeks of wound healing, with the same parameters as above, and once in 2~3 months. Second, the mechanism of action of comprehensive treatment method selection: 1, SPTL laser + prednisone treatment of this method of treatment of fast-growing capillary hemangioma and strawberry hemangioma, all belong to the true hemangioma. This kind of hemangioma is characterized by rapid growth, which may affect the functions of breathing, seeing, hearing, eating and defecating besides causing deformity, and is potentially dangerous. This kind of hemangioma has the indication of hormone therapy, and the selection method should achieve the goal of rapid inhibition of hemangioma growth and elimination of risk factors. Prednisone is a kind of glucocorticoid, which can inhibit cell mitosis and reduce vascular endothelial proliferation at the stage of lesion development, thus slowing down the growth of hemangioma and promoting tumor regression. 585 nmSPTL laser is at the peak of hemoglobin absorption, and the thermal effect produced by the lesion tissues after absorbing the laser energy will make the blood vessels contract and coagulate, and then gradually fade away due to lack of oxygen, because it is a selective photothermal effect without causing any damage to the blood vessels. Selective photothermal effect does not cause epidermal damage, and it has special effect on lesions with small and superficial vascular diameter”. There is a synergistic effect between the two combined treatments. From the clinical observation, this group basically controls the tumor development in 2~3 months of treatment and lifts the risk factors. 2.Pingyangmycin+Nd:YAG laser treatment is mainly used for oral hemangioma, the oral cavity has special function, so the treatment requires high efficacy, minimize the impact on oral function and take into account the effect of cosmetic surgery. The surgical wound is large, the wound is affected after suture and bandage, the 585nm SPTL laser penetrates shallowly and is not well absorbed by the mucous membrane containing much moisture, so it is difficult to achieve the curative effect. Therefore, intratumoral injection of paxillin is used to inhibit the synthesis of cellular DNA and cut off the DNA strand, so as to achieve the inhibition of the endothelial cell proliferation and promote the degradation of the hemangioma. Selection of Nd: YAG laser action on hemangioma after blood flow slowed down, blood viscosity increased, resulting in local acidosis and make the vascular endothelium degeneration, tissue hypoxic necrosis. It improves the total effective rate of treating hemangioma and reduces the side effects of laser and pingyangmycin accordingly. 3.SPTL laser + tretinoin treatment of hemangioma lesions does not cause harm to vital organs, but due to the lesions occurring in the fingers, and toes, palms, joints, perineum and other special parts of the dermis, the treatment is not easy to receive a good effect, and the treatment is not good enough to produce a scar or produce dysfunction. Trimethoprim is a hormone injection, the principle of action is the same as prednisone, local injection can reach the depth of the lesion, so that the thick and deep blood vessels atrophy, and no oral side effects. SPTL laser has better effect on surface lesion treatment, and the combination of the two can achieve perfect treatment of deep and shallow layers, which has good efficacy and can reduce side effects. 4.SPTL laser + CO: laser treatment of nevus erythematosus hypertrophic nodule, SPTL laser treatment will not leave scar, but clinical observation of its lesions on the nodule is difficult to work. Therefore, when a large area of nevus erythematosus lesions with SPTL laser treatment nodules, but more prominent, can not achieve the goal of cosmetic treatment. Therefore, the beginning of SPTL laser treatment for 2 times, the middle of the pulse CO: laser charring nodules to flat, and then after the stage of SFrL laser full coverage treatment for 2-3 times, which can narrow the scar caused by CO2, so that the whole surface of the lesion to restore consistency, to achieve the effect of medical aesthetics. 5.Surgery comprehensive treatment for central hemangioma of jawbone, trapezoidal hemangioma, deep hemangioma, the depth of vascular embolization treatment is not easy to grasp, especially when the hemangioma is connected with intracranial blood vessels with greater risk. Therefore, the first plastic surgery ligation of arteries, get rid of the expansion of malformed venous sinus cavity blood vessels, and then SPTL laser treatment of surface capillaries, both with the use of improved efficacy, the risk of the corresponding small, can be reduced to the minimum degree of trauma.