Non-gonococcal urethritis (NGU), is an inflammatory disease of the genitourinary tract with sexual contact as the main mode of transmission and urethritis as the main manifestation. It is mainly caused by Chlamydia trachomatis (CT) and Mycoplasma urealyticum (UU) infections, and in a few cases by Trichomonas vaginalis, Candida albicans, Staphylococcus aureus, Streptococcus, and yeast. This disease has now surpassed gonorrhea as the first sexually transmitted disease in Europe and the United States, and the number of cases in China is increasing, becoming one of the most common sexually transmitted diseases. Patients are mostly young adults, more women than men. The main clinical symptoms are frequent and urgent urination, slight itching and pain in the urethra, and thin discharge from the urethra, which belongs to the category of “gonorrhea” in Chinese medicine. Clinical manifestations Chlamydia and mycoplasma infections are characterized by a chronic course and atypical symptoms. The incubation period is 1-3 weeks, and most patients have an insidious process and no obvious clinical discomfort, so the opportunity for timely treatment is often lost. The typical manifestation of non-gonococcal urethritis in males is a painful and burning sensation in the urinary tract of varying severity, the pain is lighter than that of gonorrhea, the urethral orifice is mildly red and swollen, there is often a plasma or plasma-purulent discharge, or only in the morning the urethral orifice is found to have pus film formation, some patients have no obvious symptoms and some are asymptomatic. Second, female non-gonococcal cervicitis and urethritis female infection centered on the cervix, seen as increased leucorrhea, edema or erosion of the cervix, or pain in the lower abdomen, but the clinical symptoms are mostly not obvious. In combination or alone, urethritis can have symptoms of burning urethra or frequent urination, the urethral orifice is congested, slightly red or normal, squeezing is common with overflowing secretions, and many patients do not have any uncomfortable symptoms. The main reason for this is because of failure to treat, mis-treatment, and incomplete treatment. The most common complication for men is epididymitis, typically the symptoms of epididymitis coexist with urethritis symptoms, mostly unilateral onset; followed by prostatitis, subacute prostatitis is more common, if it is chronic prostatitis can be asymptomatic or see dull pain in the perineum, penile pain, etc. The main female comorbidities are tubal inflammation, endometritis and ectopic pregnancy. The main complications associated with men and women are infertility and infertility. Very few men can develop Reiter syndrome (manifested by urethritis, keratitis, conjunctivitis and psoriasis-like rash). IV. Other infections Mainly neonatal chlamydia (including neonatal chlamydial conjunctivitis, neonatal chlamydial pneumonia), mycoplasma pyelonephritis, habitual spontaneous abortion and chorioamnionitis, low birth weight babies, etc.