Non-gonococcal urethritis is the most common type of sexually transmitted disease in clinical practice. It is a type of disease in which urethritis is present but gonococci cannot be detected in urethral secretions, mainly caused by Chlamydia and Mycoplasma. Non-gonococcal urethritis is transmitted through sexual intercourse and invades the urogenital tract organs. So far, the incidence of this disease has surpassed that of gonorrhea in Western countries, ranking first among sexually transmitted diseases. Non-gonococcal urethritis is caused in 40%-50% of cases by Chlamydia trachomatis, and in 20%-30% of cases by Mycoplasma solium. Mycoplasma pneumoniae, human mycoplasma, and genital mycoplasma are also associated with humans, but the main causes of genitourinary infections are Mycoplasma urealyticum and human mycoplasma. Mycoplasma urealyticum has the property of decomposing urea into ammonia, which has toxic effects on cells. Mycoplasma is resistant to antibiotics that interfere with the cell wall, such as penicillin, because it has no cell wall. The incubation period of non-gonococcal urethritis is usually 7-21 days. Male patients often have urethral tingling, a burning sensation and painful urination, and a few have a slightly reddened urethral opening with frequent urination. In the morning, there is a small amount of mucus discharge from the urethra or only a scabby mouth, or a dirty crotch and a bifurcation of the urine stream when urinating. Some patients need to squeeze hard by hand to have the discharge spill out of the urethra. The symptoms are similar to those of gonorrheal urethritis, but to a lesser extent. Some patients are asymptomatic. How can male patients detect non-gonococcal urethritis early themselves? The clinical symptoms of non-gonococcal urethritis are not as obvious as those of gonorrhea. (2) A small amount of watery mucus comes out of the urethra before the first urination in the morning or after a long period of not urinating. Because of the crusty film sealing the urethra, there is a feeling of blocked urine flow or scattered urine flow at the beginning of urination. In addition, patients with non-gonococcal urethritis may also have a dual infection with gonorrhea at the same time. After regular treatment with penicillin, daikonomycin, or cephalosporin, the clinical symptoms are significantly reduced and the laboratory tests are negative for gonorrhea, but there is still a small amount of mucopurulent discharge from the urethra every day, and the urethra is mildly itchy and painful. This situation is probably due to simultaneous infection with gonorrhea and non-gonococcal urethritis. The symptoms of non-gonococcal urethritis were obvious when gonorrhea was present, and after gonorrhea was cured, the symptoms of non-gonococcal urethritis became obvious. The symptoms of non-gonococcal urethritis are not very obvious, but if not cured in time, there will be a risk of complications over time, so you should go to a hospital in time after the disease. You should not conceal your medical history from your doctor or abuse antibiotics on your own to avoid delaying treatment. Non-gonococcal urethritis can be cured as long as you cooperate with your doctor and strictly follow medical advice. Because of the long growth cycle of Chlamydia, so should be more long-term medication, and because non-gonococcal urethritis is easy to mix with other pathogens, so the use of broad-spectrum antibiotic therapy, and emphasize the need for continuous uninterrupted, regular and adequate medication, in order to completely treat.