Non-gonococcal urethritis is a sexually transmitted disease transmitted through sexual contact that has clinical manifestations of urethritis, but gonococcal infection cannot be detected in urethral secretions. Female patients have not only inflammation of the urethra but also inflammation of the genital tract such as cervicitis, so it is also called non-specific genital tract infection. This disease is increasing in China and has become one of the most common sexually transmitted diseases. [Etiology] Non-gonococcal urethritis pathogens are mainly Chlamydia trachomatis and Mycoplasma urealyticum [Clinical manifestations] The incubation period is 1-3 weeks.
(a) male non-gonococcal urethritis typically manifests as stinging urethra and mild urinary pain and burning sensation, pain is lighter than gonorrhea, the urethral orifice is mildly red and swollen, there is often plasma or plasma-purulent discharge, thinner and less than gonorrhea discharge, or only in the morning when the urethral orifice is found to have pus film formation, some patients have no obvious symptoms and some are asymptomatic. Untreated non-gonococcal urethritis often has complications, common complications are: ① epididymitis, mostly over 35 years old, typical symptoms are urethritis combined with unilateral acute epididymitis; ② prostatitis, non-gonococcal urethritis combined with subacute prostatitis, chronic prostatitis, manifested as dull perineal pain, penile pain or asymptomatic; ③ Reiter syndrome, in addition to non-gonococcal urethritis there are arthritis and (3) Reiter syndrome, in addition to non-gonococcal urethritis, there are arthritis and conjunctivitis, which usually occurs about 4 weeks after urethritis. (b) Female non-gonococcal genitourinary tract infection uterus is the main site of infection. Urethritis symptoms are not obvious, only mild urethral irritation or completely asymptomatic. Cervical edema, flushing, and erosion with hypertrophic follicles on its surface are characteristic of the appearance of cervicitis, and increased leucorrhea and postcoital bleeding may occur. There may be a close association between cervical chlamydia infection and pre-malignant or malignant stage changes of the cervix. It can be complicated by acute tubal inflammation, endometritis and ectopic pregnancy and infertility. Perinatal infection can cause neonatal chlamydial conjunctivitis or neonatal chlamydial pneumonia, and mycoplasma can cause nephritis, habitual abortion, and chorioamnionitis. [Diagnosis and differential diagnosis] The diagnosis of non-gonococcal urethritis should be based on a comprehensive analysis of clinical and laboratory test results. [Treatment] Doxycycline, minocycline, chlortetracycline, erythromycin, and ofloxacin can be used for the treatment of non-gonococcal urethritis, and the selection of drugs should be based on the results of drug sensitivity and previous treatment.