Almost all people who learn that they have glioma cannot help but ask what causes glioma? Can glioma be cured? At first I didn’t pay much attention to it, but as more and more people ask me about such questions, I feel the need to introduce you to some of the international knowledge about the etiology of glioma, and maybe it will help you to adjust your mind, life and work while you understand this general knowledge. It is now proven that under normal conditions the body stores a certain amount of stem cells in order to repair its own damage, and these stem cells are in a resting state in most cases, with the exception of bone marrow hematopoietic stem cells. In case of damage to organs and tissues, stem cells start to differentiate and renew to produce new tissue cells that can be used to repair the damaged tissues. In the same way, there is a certain amount of neural stem cells in the human brain. These stem cells are in a resting state after the brain is well developed, but when the neural tissue is damaged, the neural stem cells are activated and start to differentiate and proliferate to repair the damaged neural tissue, and under normal circumstances, this cell proliferation will stop after the tissue repair is completed. However, if this cell proliferation does not stop, a new organism will be formed, and this new organism with uncontrolled proliferation is recognized as a tumor in clinical medicine. For decades, medical doctors have been looking for factors related to the occurrence of tumors. Currently, clinical analysis and zoological experiments have confirmed that some factors are related to the occurrence of glioma, and I will briefly introduce them to you below. 1.Ionizing radiation: The chance of developing glioma will be increased if you are exposed to the environment with radiation for a long time, such as Х-ray, γ-ray, nuclear radiation, etc. 2.Hereditary factors: Here we are not saying that glioma can be inherited, but the possibility of glioma occurring in such people will increase due to the presence of some genetic factors, especially the existence of certain defects of oncogenes, with the effect of exogenous factors. 3.Nitroso compounds: These compounds have been widely present in our living environment with the development of modern industrialization, especially generated in the processing of food. 4.Polluted air: It has been confirmed that not only the chance of brain tumor is significantly increased for workers who work in air polluted environment for a long time, that is, the incidence of tumor in his children is also higher than that of other children. These occupations are mainly related to paper making, milling, handicraft, printing, chemical, oil refining and metal smelting, etc., mainly because of the presence of a large number of hydrocarbon compounds in the air. There are pesticide contaminated air is also included in this list. 5.Infection: Some animal experiments have confirmed that certain viral infections can induce brain tumors, especially during pregnancy when viral infections are a greater threat to the future of the fetus. 6. Electromagnetic waves: Some recent studies have confirmed that electromagnetic waves are harmful to human body, and long-term exposure to electromagnetic waves has a tendency to increase brain tumors. Here, I would like to remind you that cell phones are likely to be included in this list. Recently, I read a research article published by Steven Lehrer et al. in Neuro-Oncology about the relationship between cell phone and brain tumor incidence. The authors analyzed the linear relationship between primary brain tumor incidence and cell phone use in nineteen states in the United States, and finally proved that the incidence of brain tumor is closely related to cell phone use. However, so far, there is no direct evidence to prove that the use of cell phone can cause brain tumor. 7. Bad habits: such as partial eating of certain kinds of food, drinking alcohol, smoking, etc. Although there is not enough evidence that these factors are related to the occurrence of glioma, it has been confirmed that they are related to the occurrence of gastrointestinal tumors and lung tumors, etc. I have outlined above some of the factors that may be associated with the development of glioma, but in fact, glioma, like many other tumors in the human body, is not the result of a single factor. Simply put, it is likely that the combination of certain problems in one’s genetic makeup and many factors such as acquired habits and living and working environment activates the neural stem cells in the brain, leading to mutations in many genes of these stem cells, causing these stem cells to start differentiating and proliferating, and if this process is in a disorderly and uncontrolled state, glioma may occur. However, this is only an inference based on the current state of medical development, and further proof is needed in the future to determine whether this is really the case.