Gallstones usually refer to gallbladder stones, and gallbladder cancer can occur if timely treatment is not taken, and the exact time of cancer cannot be determined. Gallbladder stones tend to cause recurrent gallbladder inflammation, resulting in gallbladder atrophy and porcelain gallbladder, which is a high-risk factor for gallbladder cancer. Moreover, the larger the diameter of gallbladder stones, the higher the risk of gallbladder carcinogenesis. There is usually no definite time when gallbladder stones can progress to gallbladder cancer. However, clinically, most patients with gallbladder cancer have a history of gallbladder stones for more than 10 years, and some patients have gallbladder cancer within a few years after the discovery of gallbladder stones or even just after the discovery of gallbladder stones. For gallbladder stones with surgical indications, patients should actively undergo surgery to prevent gallbladder cancer from occurring. When gallbladder stones are combined with gallbladder polyps, the chance of gallbladder cancer will be significantly higher, so patients should have timely surgical treatment, preferably laparoscopic cholecystectomy, to reduce the possibility of gallbladder cancer.