Proteinuria is one of the most common clinical manifestations of chronic nephritis, and urine protein is also one of the important factors affecting the progression and prognosis of chronic nephritis. Clinically, a 24h urine protein quantification of more than 0.15g is called proteinuria, while more than 3.5g is called massive proteinuria, and the higher the urine protein quantification, the more serious the damage to the kidney. In general, the drugs used to treat urine protein are ACEI and ARB antihypertensive drugs, which have the effect of lowering blood pressure, and also dilate renal blood vessels, improve renal hyperfiltration, hyperperfusion and hypermetabolism, so as to reduce the effect of urine protein. Or use hormones or immunosuppressants to fundamentally control the immune response and inflammatory response in chronic nephritis disease, so as to achieve the effect of eliminating urinary protein.