Melanoma is often called “nevus”, which originates from melanocytes. Under normal circumstances, melanocytes are evenly distributed; if they divide and proliferate excessively, they become melanoma, and when such division and proliferation are out of control, they will become melanoma. Don’t give up treatment blindly. Early diagnosis of melanoma is very important. Once abnormal changes of moles in the body are found, we should seek professional doctors immediately to avoid metastasis to distant places. Melanoma can be cured by treatment in the early stage, and the survival rate of patients is about 90%, so you do not need to worry too much. The molecular targeted therapy adopted in recent years can block the growth of melanoma, which has fundamentally changed the status quo of late stage melanoma treatment. Daily self-examination can be prevented. Melanoma should be detected and treated at an early stage. Moles near the neck, palms, feet, and genitals have relatively high chances of malignant change due to frequent friction, so they should be closely observed and removed promptly or prophylactically when there are changes. Regular self-examination is an effective way to detect melanoma in time. Pay attention to the size of moles. Generally speaking, moles with a diameter greater than 0.6 cm have an increased chance of malignant transformation. Pigmented lesions with the following changes often suggest the possibility of early malignant melanoma: (1) Color: Most malignant melanomas have brown, black, red, white or blue mixed unevenly, so if a skin mole has color changes, you should be especially alert. (2) Margin: often uneven and jagged. (3) Surface: not smooth. (4) The skin around the lesion may appear edema. (5) Sensory abnormalities: local itching, burning pain or pressure pain is often present. When the above changes occur, it strongly suggests the suspicion of malignant melanoma. It can be said that once any changes occur in a skin mole, excisional biopsy should be performed to remove the malignant melanoma, without fail. The nevus should not be ordered indiscriminately. These methods often fail to remove all the mole cells and cause recurrence, and the repeated spotting of moles can cause malignant changes to the mole cells due to adverse stimulation. In addition, sometimes skin lesions that people think are “nevi” may actually be malignant lesions such as basal cell carcinoma and melanoma, which can lead to the spread of tumor cells if they are “spotted” and removed, especially for melanoma, which is a very dangerous operation and can cause rapid deterioration. If “spot” removal is performed, it can lead to the spread of tumor cells, especially for melanoma, which is a very dangerous operation and can cause rapid deterioration.