Currently, acne is classified into four grades according to the nature and severity of the lesions: Grade 1: acne only; Grade 2: inflammatory papules in addition to acne; Grade 3: pustules in addition to acne and inflammatory papules; Grade 4: nodules, cysts or scarring in addition to acne, inflammatory papules and pustules. Acne grading is an important basis for acne treatment and efficacy evaluation, and the corresponding treatment drugs and methods are often selected clinically according to its grading. Grade 1: Topical treatment is generally used. If only acne is present, topical vitamin A acid preparations are the best choice. Some medical skincare products that exfoliate, dissolve acne, inhibit sebum secretion, and are antibacterial can also be used as adjunctive treatments. Grade 2: Treatment for Grade 1 acne is usually used, but oral antibiotics may be used for those with more inflammatory papules and pustules where topical treatment is not effective. This type of acne can also be treated with a combination of oral antibiotics and topical retinoids, or with physical therapy such as red and blue light, photodynamic therapy, or fruit acid therapy. Grade 3: Patients in this category often require combination therapy, in which the systematic use of antibiotics is one of the basic treatments, and an adequate course of treatment should be ensured. The most commonly used combination therapy is oral antibiotics combined with topical retinoids, and also topical peroxynivalenol gel. Hormonal therapy can also be used with good results in women who require contraception or have other gynecological indications. Other methods such as red and blue light and photodynamic therapy can be used in combination, but attention should be paid to the interactions and contraindications between tetracyclines and isotretinoin, as well as to the development of photosensitivity. In cases of poor results, oral isotretinoin alone or topical peroxynivalenol gel can be used. For those who require more than 3 months of systemic antibiotics, the combination of peroxymethylparaben gel, an antimicrobial agent that does not cause bacterial resistance, is necessary to prevent and reduce the development of drug resistance. Level 4: Oral isotretinoin is the most effective treatment for this group of patients and can be used as first-line therapy. For patients with more inflammatory papules and pustules, a combination of systemic antibiotics and peroxynivalenol gel can be used first, and then oral isotretinoin can be used to treat cysts and nodules after the lesions have improved significantly. Combined treatment with red and blue light and photodynamic therapy can also be tried for Grade 3 acne. Regardless of the level of acne, the treatment plan is not set in stone. The dermatologist should be flexible according to the actual situation of the patient, fully reflecting the principle of individualized treatment, and should still provide the necessary maintenance treatment after the clinical symptoms have improved.