Newborns are generally prone to acne at 2-4 weeks of age, and how long it takes to heal itself depends on whether it is co-infected. Acne in newborns is related to genetics and the mother’s hormones, mainly due to androgens that increase sebum production and block the hair follicles. Some newborns have pustular lesions due to physical factors or infections, and these lesions are more severe and may even cause systemic symptoms. When acne occurs in newborns, parents should pay attention to keeping the baby’s skin clean and avoiding infection, and should not use antibiotic ointments or corticosteroid ointments on their own.