Acne on the face at the age of 35 is called post-pubertal acne. The vast majority of post-pubertal acne is caused by endocrine disorders, i.e., high androgen secretion. At the same time, we should be alert to whether there are disease factors causing it, and further clarify the cause to make a diagnosis. I. Non-disease factors: 1. Bad habits: When staying up late for a long time, the chaotic work and rest schedule can easily lead to endocrine disorders in the body. Long time not to change, clean pillow towels, pillow cases, towels, etc., will also stimulate the skin blocked pores and acne; if poor eating habits, such as like to eat spicy, stimulating, high oil, high fat, high sugar food, will lead to skin stimulation to promote oil secretion and acne; 2, skin cleaning is not in place: skin cleaning is not timely, incomplete will also cause pores blocked, causing acne growth; 3, genetic factors: because Acne has a certain family heredity, if the parents have acne during puberty, the offspring is also prone to acne; 4, drug factors: long-term use of hormones and iodide and other drugs, easy to grow acne. Second, disease factors: 1, endocrine disorders: when the body’s endocrine disorders lead to increased androgens, estrogen imbalance or metabolic disorders, will lead to excessive oil secretion and acne, such as polycystic ovary syndrome and other diseases; 2, infection: when the body’s immunity decreases, the skin barrier will also become fragile, acne bacteria breeding and reproduction and cause acne. When acne appears on the face, do not squeeze or scratch with your hands, and keep the right habits of work and rest and diet to prevent acne in your daily life.