Patient Question: Adult type polycystic kidney, Description: Hello Professor Mao! My boyfriend’s father 52 years old 2008 hematuria, to the hospital examination found to be adult type genetic polycystic kidney, my boyfriend in the doctor’s advice to do ultrasound, also found to have adult type genetic polycystic kidney. His father was hospitalized around December 2014 because of a bad cold, which caused a serious condition, the highest creatinine reached more than 1000, and then hospitalized slowly for 3 times of hemodialysis, and finally the creatinine was reduced to more than 500, after which he was discharged from the hospital and is now recuperating at home while also taking some medicine, and now the creatinine is more than 600. On January 6, 2014, my boyfriend had a genetic diagnosis, and the following are the results of the genetic diagnosis: PKD1 gene exon 15 c.5637 C>G (p.Tyr1879Term) heterozygous mutation is closely related to polycystic kidney disease, and it is more likely to be the causative mutation of polycystic kidney in this family; PKD1 gene exon 10 c.2039A>T (p.Tyr680phe) heterozygous mutation. Tyr680phe) heterozygous mutation and polycystic kidney disease is not clear. I need your help very much and I sincerely appreciate it! I would like to ask you the following questions: 1. From the results of their mutations, is this polycystic kidney mutation in their family relatively more serious than other polycystic kidneys, and what do the results mean specifically. 2. Is it better to conceive a child naturally or by third-generation in vitro fertilization? 3. Is adult polycystic kidney scary, will it cause uremia and can I have a sex life? Mao Zhiguo replied: Patients with PKD1 mutation usually progress faster than patients with PKD2 mutation, but the individual differences are still very big, so careful protection of the kidney will have a better prognosis. It is recommended to do renal MRI, kidney volume measurement, kidney function and urine test to make a comprehensive assessment. In terms of fertility, the chance of children being inherited is 50%. Genetic engineering can be used to further reduce the chance of inheritance to the offspring. If available, IVF, pre-implantation diagnosis and selective implantation can minimize the chance of inheritance in children. With polycystic kidney disease, by the age of 60, half of the patients will enter uremia and need dialysis treatment. There will be many elements to protect the kidneys, including lifestyle changes, dietary adjustments, medications in all aspects, and if there is no serious impact on kidney function leading to other complications, it usually does not affect the sex life.