The prevalence of ICA in ADPKD is about 10%, which is 4 times of the normal population; the pathological features of ADPKD are the formation and enlargement of multiple fluid cysts in the cortex and medulla of the kidney bilaterally. The increasing cysts can compress the normal renal parenchyma and produce a series of clinical symptoms, such as back pain, hematuria, hypertension, etc., which eventually lead to renal failure, and most patients can maintain normal renal function until the age of 40-60. To assess the severity of the disease and monitor the progress of the disease indicators: glomerular filtration rate, creatinine concentration, but it is not sensitive as a detection indicator. The total bilateral kidney volume in adult ADPKD patients is usually greater than 1000 ml ,while the normal adult female is 308 ml and male is 404 ml, and the bilateral kidney volume is greater than 1500 ml, mostly accompanied by a decrease in GRF. Surgical treatment of patients with early to mid stage ADPKD, around 40 years old, for advanced patients surgery is no longer meaningful, but aggravates the disease. Internal treatment, the immunosuppressant sirolimus (rapamycin) has small nephrotoxicity, and long-term application can slow down the growth of cysts and increase the renal parenchyma.