What is dominant inheritance? The gene is inherited from the father and/or mother, who carry a certain gene and develop clinical manifestations, and the gene is passed on to the next generation, which is the case of autosomal polycystic kidney, where the previous generation carries the cyst gene and develops clinical changes of polycystic kidney, and the offspring is inherited and develops polycystic kidney changes. What is recessive inheritance? This is the case of autosomal recessive polycystic kidney, in which the offspring acquire the gene through inheritance and develop polycystic kidney after the previous generation carries the gene but does not show polycystic kidney throughout life. What is the inheritance pattern of human polycystic kidney? Autosomal dominant polycystic kidney (ADPKD) is adult polycystic kidney, which follows the autosomal dominant inheritance rule, that is: 1. The children (grandchildren) will not develop the disease, that is, they will not inherit from one generation to another. What is the inheritance pattern of infantile polycystic kidney? Autosomal recessive polycystic kidney (ARPKD), or infantile polycystic kidney, is only likely to develop in children when both parents carry the gene for the disease, with a 25% chance of developing the disease and a 50% chance of passing the gene on, but the parents themselves do not have the disease, which is what recessive inheritance means. Patients often die within a few hours or days after birth, while mild cases may live to several years of age or even adulthood. Patients have markedly enlarged kidneys, which can be more than 10 times normal, and contain many radiologically arranged, relatively uniformly sized prismatic cysts (mainly made by dilated collecting ducts). Most of the patients have liver lesions (fibrosis, portal hypertension, etc.) at the same time. The degree of hepatic and renal pathology is often inversely proportional. Most eventually die from renal failure or liver comorbidities. Is polycystic kidney disease inherited from both parents? The majority of autosomal dominant polycystic kidneys (i.e., formative polycystic kidneys) (at least 75%) are inherited from parents, while a very small number (less than 25%) are not inherited from parents but are caused by genetic mutations, which may be encountered clinically in adult polycystic kidneys with no parental history; autosomal recessive polycystic kidneys are inherited from parents and The autosomal recessive polycystic kidney is inherited from both parents, and both parents must carry the gene in order to develop the disease; simple renal cysts are acquired and have a late onset, unrelated to parental inheritance; medullary sponge kidney and dysplastic polycystic kidney disease are both congenital dysplasia; acquired renal cysts are caused by long-term hemodialysis, also unrelated to parental inheritance. For large month fetuses, some of them can be found to have polycystic kidney changes through ultrasound etc. In this case, it should be carefully analyzed and case specific. The common cases are generally the following two kinds: 1. We can analyze whether the fetus has autosomal hereditary polycystic kidney through family history inquiry and several examinations, but whether it is dominant hereditary polycystic kidney (adult type polycystic kidney) or recessive hereditary polycystic kidney (infant type polycystic kidney), we should carefully decide to take the fetus, because the offspring of a polycystic kidney will have certain influence on family and society, that is, it is not in line with The principle of eugenics. 2.If the fetus is polycystic kidney dysplasia, it should be distinguished firstly whether it is unilateral or bilateral, if it is bilateral, it is better to terminate the pregnancy because of its poor prognosis; if it is unilateral, the pregnancy can be continued.