One month before the end of hepatocellular carcinoma, patients will show symptoms and signs in many parts of the body, as follows: 1. the most common local symptoms include pain in the liver area, liver mass, ascites, abdominal distension, etc.; 2. systemic symptoms, such as weakness, emaciation, poor nutrition, anemia, jaundice, general pain and discomfort, edema, and drowsiness and other impairment of consciousness; 3. when there is lung metastasis, there will be cough, shortness of breath, chest tightness, etc.; 4. In case of heart failure, there will be symptoms such as panic, palpitation and dyspnea, and gastrointestinal symptoms such as vomiting blood, blood in stool and diarrhea. In a word, one month before the end of liver cancer, patients will have symptoms of various systems, so clinicians should actively deal with them to reduce patients’ pain and give them the best end-of-life care.