Acne is a chronic skin disease that is common in young men and women, especially in young men. In some cases, acne and pimples are already present on the face during adolescence, which worsen in adulthood and gradually heal only after middle age, often leaving atrophic or keloid lesions. Due to excessive secretion of sebaceous glands and retention of large amounts of sebum in the hair follicles, sebum is gradually concentrated and decomposed by microorganisms to produce fatty acids, which can stimulate and destroy hair follicles and adnexal tissues and cause acne and other skin lesions. 1, excessive secretion of sebaceous glands: oily skin type, in the summer, sebaceous glands secretion enhanced, acne is much more serious. 2, Infection: Pathogenic microorganisms such as Acinetobacter rotundus, Staphylococcus albicans and Bacillus ovalis present on the skin surface and in local hair follicles. They do not cause major damage when normal, and when the cortical glands are blocked, they participate in the local inflammatory and non-specific inflammatory reaction of acne. Among them, Acinetobacter contains esterases that cause sebum breakdown. Esterases break down sebum in hair follicles and produce more free fatty acids, and these free fatty acids cause local inflammatory and nonspecific inflammatory reactions in and around hair follicles. The inflammatory reaction refers to the local inflammation caused by specific bacteria, redness, swelling, pain and pus head. Non-specific inflammatory reactions are those caused by non-specific bacteria with common characteristics, such as acne deep-seated hard nodules, not love the head. There are also follicular mites (parasitic human hair follicles), commonly referred to as “mites”, which reside mainly on the face, neck and forehead, with the forehead, cheeks and nose being the most common. The most numerous are on the cheeks and nose. Some people often have forehead. The “pimples” on the cheeks and nose are related to this. There are also, hair follicles gathered in one place can make the hair follicles become larger, some people performance pores obvious. 3, pore blockage: inflammation of hair follicles, hyperkeratosis, will block the pores, resulting in acne. 4, endocrine factors: androgens can stimulate sebaceous gland cells to secrete more sebum – secrete more sebum – stimulate hyperkeratosis of hair follicle ducts – make hair follicle wall hypertrophy – prevent sebum excretion. This is the initiating factor of acne. Estrogen inhibits the function of the sebaceous glands and reduces the occurrence of acne. In men, the organs that secrete androgens are the testes and adrenal glands (eunuchs who were castrated in the ancient court had fewer androgens and did not suffer from acne); in women, the ovaries, placenta and adrenal glands also secrete androgens. 5, genetic factors: If acne occurs when parents are young, the chances of acne occurring in their children at the same age are high. One is to inherit the state of skin function, such as sebaceous secretion, and the other is to inherit the state of facial response to acne. However, this is only a genetic factor, never a genetic disease, and through active prevention and proper treatment can be completely cured, not affected by genetic factors, and there are no after-effects after healing. 6, other factors: mental tension, late nights, lack of sleep can lead to sebaceous gland secretion imbalance, making acne worse; dietary habits, fatty and sugary diet, high temperature and certain chemical factors, ultraviolet radiation, etc. also play a role in the development of acne.