Lung cancer malignancy is a diagnosis of the disease and cannot represent the stage of the disease. The stage of lung cancer is determined according to the size of the tumor, the extent of tumor invasion and whether it has spread or not. Patients with advanced lung cancer are prone to brain metastasis, liver metastasis and bone metastasis, and they often show chest tightness, shortness of breath, cough, sputum and blood in sputum. Patients with brain metastasis may show dizziness, headache, nausea and vomiting, and some patients may have limited movement of one limb. Patients with bone metastasis show localized pain, and the diagnosis is often clarified by brain CT or brain MRI, as well as whole body bone scan. The treatment of advanced lung cancer is mainly based on chemotherapy and targeted therapy.