Eczema and acne are both relatively common skin diseases, but there is a big difference between the two. Eczema is an allergic disease, while acne, also known as pimples, is an inflammatory disease associated with the sebaceous glands of hair follicles.1. Location: From a clinical point of view, eczema can occur in almost all parts of the body, while acne mainly occurs on the face, forehead, back, buttocks, and other parts of the body where sebum secretion is more vigorous.2. Eczema has a polymorphic rash with erythema, papules, blisters, and even mossy skin, oozing, erosions, etc., while acne is mainly acne, inflammatory papules, pustules, nodules, etc. 3.