BCLC staging and treatment strategies, which more comprehensively consider tumor, liver function and systemic conditions, link to treatment principles, and are supported by high-level evidence of evidence-based medicine, are now widely adopted worldwide BCLC staging (Barcelona Clinical Liver Cancer Staging, 2010) Stage PS score Tumor status Liver function status Number of tumors Tumor size Stage 0: Very early 0 Single < 50px No portal hypertension Stage A: Early 0 Single 3 or less Any <75px< span=""> Child-Pugh A-B Child-Pugh A-B Stage B: Intermediate 0 Multinodular tumors Any Child-Pugh A-B Stage C: Progressive 1-2 Portal invasion or N1, M1 Any Child-Pugh A-B Stage D: End-stage 3-4 Any Any Child-Pugh C