Physical examination reveals that.
(i) If the tumor is small: usually asymptomatic.
1. No signs may be detected
2. Signs associated with chronic liver disease and/or cirrhosis
(ii) In more progressive disease.
1. palpable mass in the upper abdomen, or a harder, irregular liver surface
2. pressure pain in the upper right abdomen – splenomegaly, ascites, jaundice (also signs of cirrhosis)
3. hepatic arterial murmur (heard over the tumor)
HCC should be suspected in patients who have previously suffered from compensated cirrhosis in the presence of the following signs.
1. Rapid deterioration of liver function
2. new onset (or refractory) ascites
3. acute intra-abdominal hemorrhage
4. worsening jaundice
5. Weight loss and fever
6.New onset of hepatic encephalopathy
7. variceal bleeding
Patients with advanced HCC may present with
1, right upper abdominal pain
2, signs and symptoms of underlying cirrhosis
3.Lack of energy
4, abdominal distension
5.Non-specific digestive system symptoms
6.Jaundice
7.Poor appetite
8.Weight loss
9.Anorexia
Laboratory tests.
1.Usually non-specific
2, the manifestations of cirrhosis.
(1) thrombocytopenia
(2) Hypoproteinemia
(3) Hyperbilirubinemia
(4) Coagulation disorders