Liver cancer is a malignant tumor occurring in the liver, which is the most common type of malignant tumor. Drug therapy is one of the treatment methods for liver cancer. Nowadays, there are many kinds of drugs used in liver cancer treatment, but there are good and bad efficacy, how should patients choose the right drug for liver cancer? First of all, patients are advised to go to regular medical institutions for consultation and refer to doctors’ medication suggestions. When choosing drugs by themselves, they should pay attention to the indications of the drugs and learn more about the clinical application of the drugs. When choosing drugs for purchase, they should pay attention to whether there is an approval number to avoid buying fake drugs, follow the medication method in the instruction manual when using the drugs, and pay attention to the diet during the medication. Therefore, when choosing liver cancer drugs, patients should follow doctors’ advice instead of choosing drugs according to their own instructions, and choose the right drugs and use the right drugs to see the efficacy.