The treatment of primary liver cancer usually adopts multidisciplinary integrated treatment mainly based on surgery, i.e. surgical intervention with corresponding chemotherapy, radiotherapy or targeted drug therapy, but the specific treatment plan depends on the stage of the tumor. Early-stage hepatocellular carcinoma usually adopts radical treatment methods, such as surgical resection and local ablation. Surgical intervention is preferred, and the site of tumor can be determined by CT and MRI before surgery, and generally, complete resection of the lesion through surgery can enable to achieve the ideal therapeutic effect; secondly, radiofrequency ablation surgery can also be used. Hepatic artery embolization chemotherapy, systemic chemotherapy, molecular targeted therapy, etc. are mostly used for middle and advanced liver cancer, which can play a role in prolonging the survival time, and even have the possibility of being transformed into having surgical indications. In addition, for liver cancer patients with combined liver failure, liver transplantation can be chosen in addition to palliative treatment, but it needs to be indicated; for terminal liver cancer, only supportive and symptomatic treatment can be given. Early detection and early treatment are the most important factors to improve the prognosis of liver cancer, and standardized treatment is the guarantee to get the best treatment effect.