Unexplained discomfort or pain in the liver area, progressive aggravation of existing liver disease symptoms accompanied by loss of appetite, weight loss and general malaise should be highly alerted. Progressive enlargement of liver, pressure pain, hard texture and nodules on the surface are valuable signs (but most of them are in middle or late stage). Detection of serum markers of hepatocellular carcinoma 1. Determination of serum alpha-fetoprotein (AFP) This method has relative specificity in diagnosing this disease. The diagnosis of hepatocellular carcinoma can be considered if continuous serum AFP is ≥400μg/L by radioimmunoassay and pregnancy and active liver disease can be excluded. Clinically, about 30% of patients with hepatocellular carcinoma are negative for AFP. If AFP heterogeneous body is detected at the same time, the positive rate can be increased obviously; 2. Blood enzymology and other tumor markers examination Serum γ-glutamyl transpeptidase and its isoenzymes, abnormal prothrombinogen, alkaline phosphatase, lactate dehydrogenase isoenzymes of hepatocellular carcinoma patients can be higher than normal. However, it lacks specificity. Imaging examination 1, ultrasonography can show the size, shape and location of the tumor as well as the presence or absence of thrombus in the hepatic vein or portal vein, and its diagnostic compliance rate can reach 90%, which is a non-invasive examination method with better diagnostic value; 2, CT examination CT has high resolution, and the diagnostic compliance rate of hepatocellular carcinoma can reach more than 90%, and tiny cancerous foci with a diameter of about 25px can be detected; 3, magnetic resonance imaging (MRI) The diagnostic value is similar to that of magnetic resonance imaging (MRI). Magnetic resonance imaging (MRI) has similar diagnostic value with CT, and is better than CT in distinguishing benign and malignant intrahepatic space-occupying lesions, especially hemangiomas; 4. Selective abdominal artery or hepatic artery angiography can accurately diagnose small hepatocellular carcinomas with a diameter of 1~2Cm. It is of great significance in estimating the scope of lesions and formulating reasonable treatment plan, and it also has the unique advantages of simultaneous chemoembolization or introduction of anticancer drugs; 5. Hepatic aspiration cytology under ultrasound or CT guidance, which is applicable to those who are highly suspected but cannot be diagnosed after all kinds of examinations. It can obtain the basis of pathological diagnosis of liver cancer and understand molecular markers, etc. It is very important for clarifying the diagnosis, pathological type, judging the condition, guiding the treatment as well as evaluating the prognosis, and has been more and more adopted in recent years.