Liver cancer develops due to changes in internal and external environments, which disorganize the human body system and lead to genetic mutation. Treatment should be tailored to the needs of people, time and place, emphasizing the importance of the changes in human constitution when diagnosing and treating the disease, and determining the adaptable individualized treatment plan for different changes such as qi deficiency, blood deficiency, yin deficiency, yang deficiency, heat bloom, cold congealment, phlegm stagnation, blood paralysis and so on. In the past, there was a tendency of “treating the tumor without regard to the person” in the medical circle, and the survival period after surgery, chemotherapy and radiotherapy was less than half a year, which only paid attention to the biological effect on tumor cells in the laboratory, and it was difficult to weigh the comprehensive biological effect of chemotherapy drugs and surgery, radiotherapy and so on on the whole human body. At present, the mode of liver cancer treatment in modern medicine has shifted from extensive resection of tumor to preservation of tissues and functions, and has shifted from non-specific cytotoxicity to targeted therapy, with the emergence of new therapeutic concepts such as multidisciplinary comprehensive treatment, individualization of therapeutic protocols, preservation of functions, attention to quality of life, and emphasis on palliative and rehabilitative treatments. These therapeutic concepts, which increasingly take into account the human body’s constitution, the adaptability of the organism, as well as many biological, psychological and social factors, are in line with the holistic concept of Chinese medicine and the characteristics of evidence-based treatment. In treating liver cancer, no matter whether the symptoms are obvious or not, and the severity of the disease, one must examine the color and pulse to examine the constitution first; when choosing prescription and medication, it is emphasized that one should not overuse the products of clearing heat and removing toxins and activating blood circulation, in order to prevent more injuries to the body’s positive qi. Detoxification, pain relief, yin and yang Experimental studies have confirmed that some Chinese medicines, such as half lotus, white-flower snakeweed, septoria, fleabane, longan and so on, have certain toxic effects on tumor cells and can play an anticancer role. These Chinese medicines are mostly heat-clearing and detoxifying drugs in terms of their flavor, attribution and efficacy. Nowadays, Chinese medicine practitioners have the habit of using heat-clearing and detoxicating drugs, blood-activating drugs, softening and dispersing drugs in treating liver cancer, or even a simple stacking of the three types of drugs. This is mainly based on the understanding that “cancer is poison, fetish and firmness”, which limits the focus to the mass and ignores the patient’s physique. However, it is not known that there are cold, heat, dampness, paralysis and other yin and yang in toxicity, and there are qi stagnation, blood fetish, meridian and visceral failure, etc. Therefore, it is emphasized that yin and yang should be identified when choosing detoxifying and analgesic drugs. Yang heat evidence should be used: white flower snake tongue grass, half lotus, tiger’s stick, Yin Chen, danshen, rhinoceros horn (water buffalo horn), red peony, XuanShen and other drugs; yin and cold evidence of deficiency should be used: entertaining clams, scorpion, Chaxiang, Suhui Xiang, trigonelline, get the art of other drugs. Although liver cancer develops from Qi stagnation, phlegm coagulation and blood fatigue, it is somewhat different from Qi, phlegm and fatigue in terms of pathology. Therefore, only adopting the methods of regulating qi, eliminating phlegm and resolving paralysis is not effective in treatment, and can only be eliminated by pairing with poisons. Based on this understanding, on the basis of diagnosis and treatment, we add earthworms, water frogs, zebra meng, scorpions, amusing clams and other insect medicines to fight poison with poison, and we often receive unexpected results. With more than 25 years of clinical experience, the author believes that the basic pathogenesis of hepatocellular carcinoma is mainly caused by heat and toxicity, phlegm traces, and positive deficiency, and accordingly, the Liver Clearing and Elimination and Detoxification Dan has embodied the academic idea of “attacking toxins with toxins”. In the formula, ginseng, atractylodes, atractylodes, etc. are used to protect the spleen and stomach and assist the positive qi; earthworms, frogs and clams detoxify and eliminate swelling, activate blood circulation and alleviate pain; and white-flower snakeweed and half-stemmed lotus clear away heat and toxins; all the medicines are used in combination to play the efficacy of detoxification and anticancer. Chinese and western medicines can be used together to integrate the rationale. Liver cancer patients are mostly evil and positively deficient, however, there are many people who are deficient due to illness and few who are deficient due to illness. For early-stage liver cancer, it is imperative to get rid of the evil, and when the evil is gone, the positive will be at peace. For middle and late-stage liver cancer, most of the patients belong to the standard and the deficiency, Chinese medicine treatment should support the positive and dispel the evil, focus on the whole, and pay attention to the constitution; western medicine treatment adopts surgery, radiotherapy, intervention and other local treatments, and bio-immunotherapy. However, for the early stage of small liver cancer, the method of dispelling evil can be applied by modern medicine, such as surgery, mediator, or intratumor anhydrous alcohol injection, and it is not necessary to stick to the difference of western medicine. Most of the liver cancer patients in clinical practice have reached middle or late stage, with symptoms such as jaundice, ascites, fever, pain, etc. On the one hand, their condition is heavy and their physical condition is poor, on the other hand, they have already metastasized, therefore, single therapy often fails to achieve the expected effect, and they must be treated with a combination of traditional Chinese and western medicines, such as interventional therapy, radiofrequency ablation, biotherapy, etc. In traditional Chinese medicine, four diagnostic methods should be used for the identification of the evidence and the treatment. If the heat and toxicity of the heavy use of clearing heat and detoxification, medicines with white flower snake tongue grass, Chonglou (seven leaves of one flower), half lotus, honeysuckle, half lotus, septoria, dandelion, etc.; if the accumulation of hard lumps, the heavy use of soft and dispersal of knots, medicines with soft soft turtle shells, octopus, Xia Gu Cao, raw peony, andrographis, zhebeimu, etc.; if traces of blood obvious reuse to activate the blood and fetishization, medicinal use of salvia, trigonelline, Wenjiu, tiger’s stick, stone penetration, pingdian, panax quinquefolii, yujin, etc.; if the ascites is obvious plus water-relieving and dampening, etc.; if the If ascites is obvious, add water-inducing and dampness-permeating products, with psyllium, get and so on skin, ginger skin, zeran, etc.; if spleen deficiency and phlegm wins, add strengthening the spleen, resolving phlegm and regulating qi, with tai zi ginseng, atractylodes macrocephala, atractylodes macrocephala, Chenpi, half-sia, etc.; if liver and kidney yin deficiency, adopt nourishment of liver and kidneys, with angelica sinensis, white peony, salvia, maitake, conifers, turtle shells, raw dioxygen, cornelian cherry, etc..