Most patients with IgG4-related disease require lifelong drug therapy. A small number of patients with asymptomatic and slowly developing superficial organ involvement may be temporarily observed without drug therapy. IgG4-related disease is a chronic autoimmune disease that requires lifelong treatment with immunosuppressive drugs such as prednisone, methylprednisolone or cyclophosphamide. Immunosuppressive therapy can suppress the immune response in the body, slow down the disease process, and delay the fibrosis of various organ systems caused by IgG4-related diseases. The risk of side effects and complications is high due to the long-term use of immunosuppressive agents. A portion of asymptomatic and slowly developing superficial organ involvement, such as IgG4-associated dacryoadenitis, submandibular inflammation, and lymph node enlargement, which do not benefit much from immunosuppressive therapy all the time, can be temporarily treated without immunosuppressive therapy, and a watchful waiting strategy can be adopted. Patients with IgG4-associated diseases should go to the hospital in a timely manner, and under the guidance of the doctor to carry out regular treatment to avoid further development of the disease.