The most painful thing for kidney stone patients is renal colic, as the three unbearable pains, renal colic is the most common reason for most kidney stone patients to visit the clinic, and analgesic treatment is the first step. The most commonly used is non-steroidal anti-inflammatory drugs (diclofenac sodium 50mg nano anal, affect the glomerular filtration rate of renal insufficiency, no effect on patients with normal renal function, available 2-3 times a day suppositories), such as the first use of non-steroidal drugs is ineffective after the change to opioid analgesics, such as tramadol 50-100mg intramuscular injection, prednisone 50-100mg intramuscular injection, if necessary, pethidine 50-100 100mg intramuscular injection (the incidence of vomiting is higher than that of non-steroidal drugs). Generally analgesics are not used alone, but will be supplemented with antispasmodic drugs, such as 654-2, mebendazole, progesterone, tamsulosin, etc. For repeated analgesia-ineffective stones, emergency cystoscopic insertion of ureteral stent tubes, percutaneous nephrostomy or stone extraction are also the ultimate analgesic solutions if there is a combination of symptoms such as effusion, fever, and pyuria.