Condyloma acuminatum, also known as genital warts, is a sexually transmitted disease caused by human papilloma virus (HPV) infection that occurs in the vulva and anus; it is mainly caused by HPV types 6 and 11. As some HPV subtypes that cause warts are associated with genital cancer such as cervical cancer, they are called high-risk types, including 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, etc.; HPV associated with benign lesions such as external genital warts are called low-risk types, including 6, 11, 42, 43, 44, etc. Persistent infection of high-risk HPV types is the main cause of cervical cancer. Clinically, the disease occurs in the genital and perianal areas of both men and women. In men, it is most common around the coronal sulcus and prepuce, but also in the penis, foreskin, glans and urethra. Most of the patients are young and middle-aged people who are sexually active. Most of the patients have a history of unclean sexual contact or spouse’s history of infection before the onset of the disease. The incubation period varies from 1 to 8 months, with an average of 3 months. Occasionally, the disease is seen in children and is usually transmitted through contact with contaminated utensils such as towels. The first damage is a small, soft, light red papule, pin cap or rice grain, gradually increasing in size and number, becoming papilloma-like, cauliflower-like, cockle-like or myxoid superfluous, the surface is uneven, soft texture. If not treated in time, the warts will gradually increase in size, some become large cauliflower-shaped, the base has a tip; some fuse with each other, become a large block, light gray, the surface is papilloma-shaped, can have erosion, ulcers, there is secretion, because of secondary infection can cause malodorous. The patient usually has no conscious symptoms. There are some huge warts that can be fist-sized with papilloma-like surfaces, and the discharge often has an unpleasant odor due to secondary infection. It is a good idea to have a few of the most common types of warts in the world, such as the mucous membrane of the foreskin and the glans in men, and occasionally in the perineum and vagina in women. There are also areas where the epithelial cells have been infected with HPV, but no visible changes have yet occurred. This is called subclinical infection and can be clearly demonstrated by the vinegar white test. There is also a significant percentage of spouses or sexual partners who test positive for HPV. He/she is clinically neither damaged by acromegaly nor subclinically infected and is an HPV carrier. The common treatments for warts are physical therapy (e.g., electrocautery, carbon dioxide laser, freezing), topical medications (commonly used are 5-fluorouracil ointment, pedialyte, pedialyte toxin, peptide butylamine cream), and surgery. Each of these methods has different indications. The downside is that most warts are likely to recur after treatment, and reinfection may occur. In recent years, the use of photodynamic therapy has been promoted, its high treatment rate, low recurrence rate, non-invasive treatment times medical attention. The cytotoxic effect of monomorphic oxygen will lead to necrosis or apoptosis of the target tissue cells or affect the cell function, causing the lesion to fall off and restore the normal form and function, while the adjacent normal tissues are not affected in any way. Photodynamic therapy is more expensive, but it has good efficacy, low recurrence rate, and higher cost performance compared with traditional methods, and after 3 treatments, clinical statistics show that the treatment rate can reach 99%, while the recurrence rate is only 10%. Traditional treatment methods, such as carbon dioxide laser, although visible warts are rapidly eliminated after cauterization, but often can not remove subclinical and latent lesions, resulting in ineffective treatment, after a few weeks to a few months will recur, the overall recurrence rate will be more than 40% or higher. Currently, clinicians use a variety of systemic and local medications in addition to CO2 laser treatment, which not only takes longer to treat and affects the patient’s daily life, but also costs more for the overall treatment. The high treatment rate and low recurrence rate is just one of the cost-effective aspects of photodynamic treatment of warts. Photodynamic treatment of warts is non-invasive and can maintain the integrity of normal cells and organs to the maximum.